Acuitas Poster Presentations at ASGCT Annual Meeting

Acuitas Therapeutics, Inc.’s Chief Scientific Officer, Dr. Ying Tam, and Vice President, Preclinical Research, Sean Semple, will deliver two poster presentations at the American Society of Gene & Cell Therapy’s (ASGCT) Annual General Meeting from May 7 – 11, 2024, in Baltimore, Maryland. Several other members of the Acuitas team, including scientists and the business development team, will also attend the event.

As the global leader in lipid nanoparticle (LNP) delivery systems, members of the Acuitas team are well positioned to share recent research and data with scientific peers and colleagues from around the world who are also attending the prestigious event.

Dr. Tam’s poster presentation (1243) is on Spatial Resolution of mRNA Lipid Nanoparticle-Based In Vivo Base Editing in the Liver of Mice and Monkeys. It explores repeated administration of mRNA lipid nanoparticles to enable effective delivery of gene editing systems following intravenous administration, offering several potential advantages compared to viral delivery, including an improved safety profile, larger payload capacity, and the opportunity to repeat dose. This describes work to evaluate spatial editing in individual cells within the liver. You can find more information on this presentation here; it will be featured on Thursday, May 9, 2024 in the Exhibit Hall.

Sean Semple’s poster presentation (1755) is on Pharmacokinetics and Distribution of Lipid Nanoparticle Formulations of mRNA in Gonadal Tissues in Rat and Monkey. With the increasing use of LNP for gene editing and other RNA-based therapeutics, this presentation focuses on the essential need for a detailed understanding of LNP distribution to support the safety assessment of these therapeutics and to identify cell types for further investigation of on- and off-target editing. You can find more information on this presentation here; it will be featured on Friday, May 10, 2024 in the Exhibit Hall.