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Releasing the Brakes on CAR T-Cell Therapy with DARPin-conjugated LNP for In Vivo Delivery

Designing an in vivo cell therapy that appropriately balances efficacy and safety remains a significant challenge; however DARPin-conjugated LNP have shown promise on both counts in preclinical studies.

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Acuitas Therapeutics Highlights In Vivo CAR T Engineering and Lipid Quality at 2026 ASGCT Meeting

Read about Acuitas Therapeutics Highlights In Vivo CAR T Engineering and Lipid Quality at 2026 ASGCT Meeting

Cargo-free LNP Manufacturing Could Spark a Nucleic Acid Therapy Renaissance

Combining pre-formed vesicles with nucleic acid cargo at the point of care can remove long-standing barriers to personalized nucleic acid therapeutics.

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CAR-T cell therapies going in vivo

Read about CAR-T cell therapies going in vivo

Inside Acuitas Therapeutics: The Vancouver Life Science Lab Powering Medical Breakthroughs

Acuitas Therapeutics shelled out an undisclosed sum to acquire a majority stake in Montreal-based and privately held RNA Technologies & Therapeutics.

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Why Does the Future of Genetic Medicines Rely on LNP Targeting Strategies? Read What Experts Have to Say

Active targeting via site-specific ligand attachment, including DARPin conjugation, enables high-affinity cell recognition and has shown ~90% mRNA expression in human CD8⁺ T cells, supporting in-vivo CAR-T concepts.

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Optimising potency and delivery: the new frontier of LNP in mRNA cancer vaccines

Optimising potency and delivery: the new frontier of LNP in mRNA cancer vaccines.

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Biotech Firms Cement a Longstanding Collaboration via Strategic Investment

Read about Biotech Firms Cement a Longstanding Collaboration via Strategic Investment

Acuitas Therapeutics Buys Majority Stake In RNA Technologies & Therapeutics

Read about Acuitas Therapeutics Buys Majority Stake In RNA Technologies & Therapeutics

Acuitas Takes Majority stake in Montreal-based RNA Construct Manufacturer

Acuitas Therapeutics shelled out an undisclosed sum to acquire a majority stake in Montreal-based and privately held RNA Technologies & Therapeutics.

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Acuitas Therapeutics: Interview With President & CEO Dr. Thomas Madden About The Biotech Company

Read about Acuitas Therapeutics: Interview With President & CEO Dr. Thomas Madden About The Biotech Company

A Year of Firsts: Personalized Gene Editing Comes of Age

Read about A Year of Firsts: Personalized Gene Editing Comes of Age