Acuitas Therapeutics

Headquarters

6190 Agronomy Road, Suite 402 Vancouver BC V6T 1Z3 Canada

Email: info@acuitastx.com
Facebook: @Acuitas
Twitter: @Acuitastx
Acuitas: noun, insight, perception, sharpness.

EXPERTISE AND CAPABILITIES

Acuitas Scientists Have Extensive Experience and Expertise in LNP Development and Characterization

ABOUT OUR TECHNOLOGY

Acuitas scientists have extensive experience and expertise in the development and characterization of LNP delivery systems for nucleic acid therapeutics.
The R&D areas we support are indicated below:

SYNTHETIC CHEMISTRY

  • Design and synthesis of novel lipids (e.g., cationic, pegylated).
  • Radiolabeled and stable-isotope lipids to support ADME studies
  • Synthetic process technology transfer to Contract Manufacturing Organization (CMO)

PRODUCT FORMULATION, SCALE-UP AND cGMP MANUFACTURE

  • Formulation development and optimization using scaleable components and processes
  • Process characterization and optimization
  • Manufacturing process technical transfer to cGMP CMO

ANALYTICAL AND BIOPHYSICAL CHARACTERIZATION

  • Analytical methods development and transfer, including lipid and nucleic acid specific analyses
  • Biophysical characterization including LNP size and size distribution encapsulation, surface charge and pKa, cryo-electron microscopy, 31P-NMR
  • Bioanalytical method development and analyses for LNP components

PRECLINICAL CHARACTERIZATION

  • Pharmacodynamic studies for protein replacement therapeutics
    • Reporter gene (e.g., luciferase, green fluorescent protein) expression in vivo by fluorescent/luminescent live imaging
    • Reporter tissue/cell gene expression ex vivo by flow cytometry, fluorescence microscopy, or fluorescence/luminescence spectroscopy
    • Transgene expression by immunohistochemistry/ immunocytochemistry
  • Safety/Tolerability studies
    • Clinical pathology/histopathology
    • Immune response characterization (e.g., complement, cytokines/chemokines)
  • Bioanalytical
    • Nucleic acid therapeutic
    • LNP components

PROGRAM AND ALLIANCE MANAGEMENT

  • Focuses on successful management of the program to meet partner objectives
    • Coordination and execution of Partner Work Plan
    • Monitoring budget, resources, and timelines
  • Catalyses a strengthened partnership alliance to ensure excellent alignment on deliverables
    • Regular communication with partner project/program management team to ensure alignment
    • Management of objectives, agendas, material preparation, attendees and logistics for semi-annual Face to Face meetings